By rental car from Mendoza to Salta

About the Ruta 40 from Mendoza to Salta (or vice versa)

Federico Garcia

By rental car from Mendoza to Salta

About the Ruta 40 from Mendoza to Salta (or vice versa)

Federico Garcia

By rental car from Mendoza to Salta

The world famous Ruta 40

A spectacular tour by rental car for those who want to get to know the Andes and the impressive emptiness of the interior at their own pace! Mendoza's world-famous wine region is the relaxing beginning or end point. During the trip, follow part of the legendary ruta 40,the world's longest road. Along the way, visit the deep canyon of Talampaya National Park and drive by private hire car through provincial park Ischigualasto (Maanvallei); You really feel like you're on another planet! The route from Cafayate via colonial Cachi to Salta (or vice versa) is spectacular, varied and breathtakingly beautiful and is number one of our journeys by rental car.

Tips & Tops Per rental car from Mendoza to Salta:

  • When you stay in Mendoza in March, you can be part of the harvest festivals.
  • Combine Mendoza with the Colchagua Valley and Santiago wine region in Chile. You will then cross the Andes from Mendoza along the Aconcagua (highest peak in South America!) to Santiago de Chile.
  • This trip can be well combined with the Atacama Desert in Chile (see for example The North Deluxe). You will then cross from Salta over the high spectacular passes of the Andes to San Pedro de Atacama in Chile.
  • You can also drive from Salta further north and explore the Humahuaca Gorge with its Indian villages.
  • Extend your stay with delicious gourmet indulgence at one of the wineries around Mendoza, we recommend the topper Cavas Wine Lodge.
  • Take a look at our other recommended accommodations: Patios de Cafayate, Hacienda de Molinos, Merced del Alto in Cachi and Hotel Legado Mitico – Salta.
  • We can offer this trip in different accommodation categories.

Your tailor-made trip

Daily overview

1 Arrival in Mendoza
2-5 Self drive north via provincial park Ischigualasto (Valley of the Moon) and Talampaya National Park (red mountains)
6-7 Self drive to Cafayate with the beautiful quebrada de las Conchas (along the way towards Salta)
8-9 Via ruta 40 to colonial Molinos, Cachi and national park los Cardones (with huge cacti) to Salta
10-11 Stay in colonial Salta or on a finca outside the city

Highlights for this trip

Inspiration trips for Argentina